Atlas of Brain Perfusion SPECT

Radiolabeled Agents for Brain Perfusion SPECT

In addition to their use in determining perfusion, radiotracers can also be used to determine biochemical interactions such as receptor binding.

Iodine-123-QNB (quinuclidinyl-iodo-benzilate), an acetylcholine muscarinic antagonist, has been used to image these receptors in the brains of normal subjects and patients with Alzheimer's disease.
Iodine-123-Iodine labeled ligands IBZM and IBZP (iodo-hydroxy-methoxy-N-[(ethyl-pyrrolidinyl) methyl]-benzamide and chloro-hydroxy-iodophenyl-methyl-tetrahydro-H-benzapine) have been developed for imaging the dopamine receptor system and may prove useful in studies of Parkinson's disease and other movement disorders as well as in schizophrenia.
Iodine-123 labeled ligands have been used for imaging the benzodiazapine and the serotonin receptors. These radiotracers, however, have not yet reached the stage of routine clinical practice, as a consensus on measuring receptor binding using single-photon tracers has not yet been reached nor have diagnostic clinical strategies been identified.

Comments and errors to Chandak@dsg.harvard.edu. Information on images through Basem@bwh.harvard.edu.
Last updated: July 18, 1995.