Reversible Perfusion Defects

Severe Stress-induced Ischemia
with Normal Baseline

FINDINGS

IMPRESSION
FULL SIZE (large) . . . SCREEN SIZE
IMAGES
HISTORY
(TUTORIAL)
TITLE PAGE
FULL SIZE (large) . . . SCREEN SIZE
CONTENTS
PREVIOUS
CASE
NEXT CASE
Impression:

  • Severe stress-induced changes in the lateral wall from the base to the apex (small lines) -- consistent with severe ischemia (5/25 segments; about 20% of the total myocardial volume) (LCX territory).

  • Quantification shows that 19% of the myocardium is involved. The severity score is high (499). The quantification also shows a rest perfusion abnormality in the inferior-lateral wall which is not appreciated in the images. A minor injury is therefore possible but not proven.

  • There appears to be a significant increase in LV cavity size in the stress study. This is partly due to suboptimal alignment and partly to the severe ischemia in the lateral wall. Still, even considering the above, the cavity size does appear to increase, thus indicating subendocardial ischemia, reasonably secondary to LV failure and associated increase in LV EDP.

    Coronary angiography:

  • LAD - 30-40% proximal stenosis
    - 1st marginal branch - 40% proximal stenosis
  • LCX - Totally occluded distally
  • OM - 95% stenosis
  • RCA - Small and totally occluded (non-dominant)

    Comments:
    LCX and RCA are occluded, but the lateral and inferior walls still show normal perfusion at rest. This appearence can be explained by sufficient collateral flow to the lateral wall at rest, and developement insufficiency of collaterals during stress, first in the lateral wall.


  • MARKED IMAGES (TOP)



    Atlas of Myocardial Perfusion SPECT
    © Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA

    Comments and errors to atlasspect@yahoo.com
    Contributions and case related information through
    Fmannting@bics.bwh.harvard.edu
    Please include URL reference with correspondence
    Initiated: Nov 19, 1995. Last updated: April 26, 1999.