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Coronary Artery Disease and CT Imaging of the Heart

This question-and-answer guide will help you understand the test and let you know what to expect before, during and after the procedure.

Brigham and Women's Hospital (BWH) has been at the forefront of CT scanning since its introduction. In fact, BWH had the first state-approved body CT scanner and has been performing CT scans since 1977.

BWH now possesses four state-of-the-art CT scanners, each of which can perform "spiral" CT, giving the latest technology for the best patient care.

Frequently Asked Questions

What is coronary artery disease?
Am I at risk of having or getting coronary artery disease?
What should I do to prevent coronary artery disease?
CT Imaging of the Heart and Coronary Calsium Screening - what can it do for me?

Other Investigational CT Scan Procedures:



1. What is coronary artery disease?
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The coronary arteries are the vessels that supply the heart with blood, which carries oxygen and nutrients. Coronary artery disease is, simply, the narrowing of these vessels. This narrowing is caused by a three-step process:
1. Cholesterol and other fatty materials are deposited on the walls of the vessels, and the body naturally surrounds these foreign materials with scar tissue. This scar-covered deposit—literally forming a lump on the inside of the vessel—is called “plaque.”
2. The plaque continues to build up over time. New deposits form around the uneven texture of existing plaques. The process causes the affected section of the artery to lose flexibility and become hard. This is called “atherosclerosis.”
3. Eventually, plaque reduces the interior diameter of the vessel and restricts the flow of blood. Sometimes, the deposits completely occlude—block—the artery.
When blood flow is reduced, less oxygen is carried to the heart muscle. Lack of oxygen may cause pain (“angina pectoris”) or even the destruction of a portion of the heart muscle (myocardial infarction or “heart attack”).

Coronary artery disease is the leading cause of death in the United States. Each year more than 750,000 Americans experience a myocardial infarction; this heart attack is often the first sign of their coronary artery disease. The annual costs associated with caring for patients with coronary artery disease are a tremendous burden to the healthcare system.



2. Am I at risk of getting coronary artery disease?
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The risk factors linked to coronary artery disease are well known. They include high cholesterol (and other blood lipids), high blood pressure, and a family history of coronary artery disease, among others. If you have any of these conditions, you have an increased risk of having or getting coronary artery disease. Smoking cigarettes is also an important risk behavior. If you smoke, you are far more likely than a non smoker to have or develop coronary artery disease.



3. What should I do to prevent coronary artery disease?
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The most important factor in determining your risk for having or developing coronary artery disease is your lifestyle. The best prevention against coronary artery disease is to quit smoking, to eat a healthy, balanced diet, and to exercise on a regular basis. If these steps are insufficient to reduce your cholesterol or blood pressure to normal levels, medications may also be helpful.

If you are affected by factors that put you at a higher risk of having or getting coronary artery disease (see above), you should consult with a cardiologist, internist or family practitioner. These physicians can help you make lifestyle changes to protect your health.



4. CT Imaging of the Heart and Coronary Calcium Screening - what can it do for me?
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Computed tomography (CT) scanning—also known as computed axial tomography, or CAT scanning—is being investigated as a method of detecting coronary artery disease early. The CT scanner consists of a patient couch and an open ring that rotates around the patient during the test. Advanced x-ray equipment is mounted on the ring. As the ring rotates around the patient, the x-ray “cameras” acquire cross-sectional images of the heart and surrounding arteries. In our institution, only cutting-edge CT scanners are used for imaging of the heart and coronary arteries. These state of the art scanners acquire high-resolution images in the shortest possible length of time. In fact, each individual image is obtained so quickly that it appears motion-free, even as the heart continues to beat normally. The procedure is painless. Since it is a type of x-ray procedure, however, there is some radiation exposure during the exam. By using only high-speed scanners and low-dose technology, we are able to minimize that exposure. In our facility, a patient undergoing CT screening for coronary artery disease will be exposed to approximately the same amount of radiation he or she would normally absorb from background sources—such as the sun—in one year.

CT scanning can be used to assess a person’s risk for coronary artery disease in two ways. The first approach is called “coronary calcium screening.” In this procedure, the CT scanner is used to detect, count and measure calcifications—deposits of calcium—within the coronary arteries. These deposits of calcium are known to indicate atherosclerosis. Unusual amounts of calcifications may be the first sign of developing coronary artery disease; they can often be found before symptoms occur and even before other tests such as an EKG or treadmill testing (so-called “stress testing”) indicate the presence of the disease.

If you are over the age of 60 years, do not smoke and have normal amounts of calcification in your coronary arteries on CT coronary calcium screening, your likelihood of having coronary artery disease is extremely low. Most patients over 60 do have some degree of calcification in their coronary arteries. Only abnormally high levels of coronary calcium would indicate an increased risk of coronary artery disease. If abnormal calcification is found on your CT images, it may lead your physician to evaluate you or treat your symptoms more aggressively.

In some instances, coronary artery disease may be present without calcifications. If you are under the age of 60 and have other risk factors (for example, if you are an active smoker or have high cholesterol or a family history of coronary artery disease), you could have coronary artery disease without calcifications. In these cases, contrast-enhanced CT images of the coronary artery walls can help doctors find noncalcified (“soft”) plaque. A “contrast agent” is a substance that shows up very clearly and very distinctly on the CT image. Images taken when a contrast agent is in the bloodstream can show irregularities in the artery walls and stenoses (narrow areas), which may indicate the presence of soft plaques. This procedure is under active investigation at this time.

If you experience symptoms of coronary artery disease, such as chest pain when resting or exercising, you should talk to your primary care physician. He or she will determine what diagnostic tests may be appropriate for you.


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